Boundaries of the Construct of Unemployment in the Pre-Retirement Years: Exploring an Expanded Measurement of Lost-Work Opportunity

There is uncertainty related to whether retirement negatively affects health—possibly due to complexity around retirement decisions. Lost-work opportunity through unemployment or forced retirement has been shown to negatively affect health. Lost-work opportunity can be captured in two measurement fields, either a reported experience of being forced into retirement or reported unemployment. However, 17% of individuals retiring due to the loss of work opportunity identified in qualitative interviewing (i.e., unemployment, temporary lay-offs, company buy-outs, forced relocations, etc.) do not report this unemployment or involuntary retirement in quantitative survey responses. We propose broadening the conceptualization of late-career unemployment to incorporate other lost work opportunity scenarios. Using the Health and Retirement Study (HRS), a lost-work opportunity score (LOS) was computed from items indicating unemployment and forced or unplanned retirement. Correlations were computed between this LOS and all continuous variables in the RAND longitudinal compilation of the HRS to determine its convergent and discriminant validity. The LOS demonstrated a Chronbach’s alpha of α = .82 and had convergent validity with constructs of employment (9 variables), finances (36 variables), and health (14 variables), as predicted by the literature on retirement timing. No other continuous variables in the HRS were identified with a moderate or strong correlation to LOS, demonstrating discriminant validity. Further research should explore whether a combination of variables in the HRS can improve the accuracy of measuring lost-work opportunity. Improved precision in measurement, through an expanded conceptualization of lost-work opportunity, may help explicate the retirement-related factors that affect health, to inform policy and support healthy aging decisions at a societal level

Resveratrol retards progression of diabetic nephropathy through modulations of oxidative stress, proinflammatory cytokines, and AMP-activated protein kinase

<p>Abstract</p> <p>Background</p> <p>Diabetic nephropathy (DN) has been recognized as the leading cause of end-stage renal disease. Resveratrol (RSV), a polyphenolic compound, has been indicated to possess an insulin-like property in diabetes. In the present study, we aimed to investigate the renoprotective effects of RSV and delineate its underlying mechanism in early-stage DN.</p> <p>Methods</p> <p>The protective effects of RSV on DN were evaluated in streptozotocin (STZ)-induced diabetic rats.</p> <p>Results</p> <p>The plasma glucose, creatinine, and blood urea nitrogen were significantly elevated in STZ-induced diabetic rats. RSV treatment markedly ameliorated hyperglycemia and renal dysfunction in STZ-induced diabetic rats. The diabetes-induced superoxide anion and protein carbonyl levels were also significantly attenuated in RSV-treated diabetic kidney. The AMPK protein phosphorylation and expression levels were remarkably reduced in diabetic renal tissues. In contrast, RSV treatment significantly rescued the AMPK protein expression and phosphorylation compared to non-treated diabetic group. Additionally, hyperglycemia markedly enhanced renal production of proinflammatory cytokine IL-1β. RSV reduced IL-1β but increased TNF-α and IL-6 levels in the diabetic kidneys.</p> <p>Conclusions</p> <p>Our findings suggest that RSV protects against oxidative stress, exhibits concurrent proinflammation and anti-inflammation, and up-regulates AMPK expression and activation, which may contribute to its beneficial effects on the early stage of DN.</p

SDSS1133: An Unusually Persistent Transient in a Nearby Dwarf Galaxy

While performing a survey to detect recoiling supermassive black holes, we have identified an unusual source having a projected offset of 800 pc from a nearby dwarf galaxy. The object, SDSS J113323.97+550415.8, exhibits broad emission lines and strong variability. While originally classified as a supernova (SN) because of its nondetection in 2005, we detect it in recent and past observations over 63 yr and find over a magnitude of rebrightening in the last 2 years. Using high-resolution adaptive optics observations, we constrain the source emission region to be <12 pc and find a disturbed host-galaxy morphology indicative of recent merger activity. Observations taken over more than a decade show narrow [O III] lines, constant ultraviolet emission, broad Balmer lines, a constant putative black hole mass over a decade of observations despite changes in the continuum, and optical emission-line diagnostics consistent with an active galactic nucleus (AGN). However, the optical spectra exhibit blueshifted absorption, and eventually narrow Fe II and [Ca II] emission, each of which is rarely found in AGN spectra. While this peculiar source displays many of the observational properties expected of a potential black hole recoil candidate, some of the properties could also be explained by a luminous blue variable star (LBV) erupting for decades since 1950, followed by a Type IIn SN in 2001. Interpreted as an LBV followed by a SN analogous to SN 2009ip, the multi-decade LBV eruptions would be the longest ever observed, and the broad Halpha emission would be the most luminous ever observed at late times (>10 yr), larger than that of unusually luminous supernovae such as SN 1988Z, suggesting one of the most extreme episodes of pre-SN mass loss ever discovered.Comment: Accepted for publication in MNRA

Melioidosis Outbreak after Typhoon, Southern Taiwan

From July through September 2005, shortly after a typhoon, 40 cases of Burkholderia pseudomallei infection (melioidosis) were identified in southern Taiwan. Two genotypes that had been present in 2000 were identified by pulsed-field gel electrophoresis. Such a case cluster confirms that melioidosis is endemic to Taiwan

Development of a Recommender System for Dental Care Using Machine Learning

Resource mismanagement along with the underutilization of dental care has led to serious health and economic consequences. Artificial intelligence was applied to a national health database to develop recommendations for dental care. The data were obtained from the 2013–2014 National Health and Nutrition Examination Survey to perform machine learning. Feature selection was done using LASSO in R to determine the best regression model. Prediction models were developed using several supervised machine learning algorithms, including logistic regression, support vector machine, random forest, and classification and regression tree. Feature selection by LASSO along with the inclusion of additional clinically relevant variables identified 8 top features associated with recommendation for dental care. The top 3 features include gum health, number of prescription medications taken, and race. Gum health shows a significantly higher relative importance compared to other features. Demographics, healthcare access, and general health variables were identified as top features related to receiving additional dental care, consistent with prior research. Practicing dentists and other healthcare professionals can follow this model to enable precision dentistry through the incorporation of our algorithms into computerized screening tool or decision tree diagram to achieve more efficient and personalized preventive strategies and treatment protocols in dental care

A pilot controlled trial of a combination of dense cranial electroacupuncture stimulation and body acupuncture for post-stroke depression

Our previous studies have demonstrated the treatment benefits of dense cranial electroacupuncture stimulation (DCEAS), a novel brain stimulation therapy in patients with major depression, postpartum depression and obsessive-compulsive disorder. The purpose of the present study was to further evaluate the effectiveness of DCEAS combined with body acupuncture and selective serotonin reuptake inhibitors (SSRIs) in patients with post-stroke depression (PSD).published_or_final_versio

Organization of Block Copolymers using NanoImprint Lithography: Comparison of Theory and Experiments

We present NanoImprint lithography experiments and modeling of thin films of block copolymers (BCP). The NanoImprint lithography is used to align perpendicularly lamellar phases, over distances much larger than the natural lamellar periodicity. The modeling relies on self-consistent field calculations done in two- and three-dimensions. We get a good agreement with the NanoImprint lithography setups. We find that, at thermodynamical equilibrium, the ordered BCP lamellae are much better aligned than when the films are deposited on uniform planar surfaces

SDSS1133: an unusually persistent transient in a nearby dwarf galaxy

While performing a survey to detect recoiling supermassive black holes, we have identified an unusual source having a projected offset of 800 pc from a nearby dwarf galaxy. The object, SDSS J113323.97+550415.8, exhibits broad emission lines and strong variability. While originally classified as a supernova (SN) because of its non-detection in 2005, we detect it in recent and past observations over 63yr and find over a magnitude of rebrightening in the last 2yr. Using high-resolution adaptive optics observations, we constrain the source emission region to be ≲12 pc and find a disturbed host-galaxy morphology indicative of recent merger activity. Observations taken over more than a decade show narrow [O iii] lines, constant ultraviolet emission, broad Balmer lines, a constant putative black hole mass over a decade of observations despite changes in the continuum, and optical emission-line diagnostics consistent with an active galactic nucleus (AGN). However, the optical spectra exhibit blueshifted absorption, and eventually narrow Fe ii and [Ca ii] emission, each of which is rarely found in AGN spectra. While this peculiar source displays many of the observational properties expected of a potential black hole recoil candidate, some of the properties could also be explained by a luminous blue variable star (LBV) erupting for decades since 1950, followed by a Type IIn SN in 2001. Interpreted as an LBV followed by an SN analogous to SN 2009ip, the multidecade LBV eruptions would be the longest ever observed, and the broad Hα emission would be the most luminous ever observed at late times (>10yr), larger than that of unusually luminous SNe such as SN 1988Z, suggesting one of the most extreme episodes of pre-SN mass-loss ever discovere